The Antifungal Effect of Garlic Essential Oil on Phytophthora nicotianae and the Inhibitory Component Involved.
Identifieur interne : 000371 ( Main/Exploration ); précédent : 000370; suivant : 000372The Antifungal Effect of Garlic Essential Oil on Phytophthora nicotianae and the Inhibitory Component Involved.
Auteurs : Yaochen Wang [République populaire de Chine] ; Keke Wei [République populaire de Chine] ; Xiaobin Han [République populaire de Chine] ; Donglin Zhao [République populaire de Chine] ; Yanfen Zheng [République populaire de Chine] ; Jianmin Chao [République populaire de Chine] ; Jianyu Gou [République populaire de Chine] ; Fanyu Kong [République populaire de Chine] ; Cheng-Sheng Zhang [République populaire de Chine]Source :
- Biomolecules [ 2218-273X ] ; 2019.
Descripteurs français
- KwdFr :
- Ail (composition chimique), Antifongiques (pharmacologie), Composés allyliques (pharmacologie), Disulfures (pharmacologie), Huile essentielle (pharmacologie), Maladies des plantes (microbiologie), Parties aériennes de plante (composition chimique), Phytophthora (effets des médicaments et des substances chimiques), Relation dose-effet des médicaments (MeSH), Relation structure-activité (MeSH), Tabac (effets des médicaments et des substances chimiques), Tabac (microbiologie), Tests de sensibilité microbienne (MeSH).
- MESH :
- composition chimique : Ail, Parties aériennes de plante.
- effets des médicaments et des substances chimiques : Phytophthora, Tabac.
- microbiologie : Maladies des plantes, Tabac.
- pharmacologie : Antifongiques, Composés allyliques, Disulfures, Huile essentielle.
- Relation dose-effet des médicaments, Relation structure-activité, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Allyl Compounds (pharmacology), Antifungal Agents (pharmacology), Disulfides (pharmacology), Dose-Response Relationship, Drug (MeSH), Garlic (chemistry), Microbial Sensitivity Tests (MeSH), Oils, Volatile (pharmacology), Phytophthora (drug effects), Plant Components, Aerial (chemistry), Plant Diseases (microbiology), Structure-Activity Relationship (MeSH), Tobacco (drug effects), Tobacco (microbiology).
- MESH :
- chemical , pharmacology : Allyl Compounds, Antifungal Agents, Disulfides, Oils, Volatile.
- chemistry : Garlic, Plant Components, Aerial.
- drug effects : Phytophthora, Tobacco.
- microbiology : Plant Diseases, Tobacco.
- Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Structure-Activity Relationship.
Abstract
This study explored the chemical compositions of garlic essential oil, the inhibitory activity of garlic essential oil and diallyl disulfide (DADS) against Phytophthora nicotianae, and the effects on mycelial plasma membrane permeability and P. nicotianae inhibition. In total, 29 compounds were detected in garlic essential oil, of which 26 were detected by gas chromatography‒mass spectrometry (GC-MS) and 21 by headspace solid-phase microextraction (HS-SPME) GC-MS. DADS (60.12% and 19.09%) and trisulfide di-2-propenyl (14.18% and 17.98%) were the major components identified by HS-SPME GC-MS and GC-MS analysis, respectively. Half-inhibitory concentration (Ec50, antagonism) and minimum inhibitory concentration (MIC, fumigation) of DADS against P. nicotianae were 150.83 μL/L and 20 μL/L, respectively, while Ec50 of garlic essential oil was 1108.25 μL/L. Mycelial membrane permeability gradually increased in a concentration-dependent manner, and cell death increased at 450 μL/L DADS. Furthermore, DADS treatment significantly reduced the incidence of tobacco black shank and the number of P. nicotianae pathogens in rhizosphere soil. DADS also promoted root development of tobacco seedlings at low concentrations, which was inhibited at high concentrations. Therefore, DADS may play an important role in the antifungal effect against P. nicotianae by destroying mycelial cell membrane integrity, causing an increase in cell membrane permeability, and leading to cell death.
DOI: 10.3390/biom9100632
PubMed: 31640228
PubMed Central: PMC6843687
Affiliations:
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sort="Gou, Jianyu" uniqKey="Gou J" first="Jianyu" last="Gou">Jianyu Gou</name><affiliation wicri:level="1"><nlm:affiliation>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100, China. goujianyu1975@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100</wicri:regionArea><wicri:noRegion>Zunyi 563100</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Fanyu" sort="Kong, Fanyu" uniqKey="Kong F" first="Fanyu" last="Kong">Fanyu Kong</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. kongfanyu@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of 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Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Keke" sort="Wei, Keke" uniqKey="Wei K" first="Keke" last="Wei">Keke Wei</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. kekewei1995@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Han, Xiaobin" sort="Han, Xiaobin" uniqKey="Han X" first="Xiaobin" last="Han">Xiaobin Han</name><affiliation wicri:level="1"><nlm:affiliation>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100, China. hanxiaobin2011@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100</wicri:regionArea><wicri:noRegion>Zunyi 563100</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Donglin" sort="Zhao, Donglin" uniqKey="Zhao D" first="Donglin" last="Zhao">Donglin Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhaodonglin@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Yanfen" sort="Zheng, Yanfen" uniqKey="Zheng Y" first="Yanfen" last="Zheng">Yanfen Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhengyanfen@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Chao, Jianmin" sort="Chao, Jianmin" uniqKey="Chao J" first="Jianmin" last="Chao">Jianmin Chao</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. caojianmin@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Gou, Jianyu" sort="Gou, Jianyu" uniqKey="Gou J" first="Jianyu" last="Gou">Jianyu Gou</name><affiliation wicri:level="1"><nlm:affiliation>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100, China. goujianyu1975@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100</wicri:regionArea><wicri:noRegion>Zunyi 563100</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Fanyu" sort="Kong, Fanyu" uniqKey="Kong F" first="Fanyu" last="Kong">Fanyu Kong</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. kongfanyu@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Cheng Sheng" sort="Zhang, Cheng Sheng" uniqKey="Zhang C" first="Cheng-Sheng" last="Zhang">Cheng-Sheng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhangchengsheng@caas.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101</wicri:regionArea><wicri:noRegion>Qingdao 266101</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allyl Compounds (pharmacology)</term><term>Antifungal Agents (pharmacology)</term><term>Disulfides (pharmacology)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Garlic (chemistry)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Oils, Volatile (pharmacology)</term><term>Phytophthora (drug effects)</term><term>Plant Components, Aerial (chemistry)</term><term>Plant Diseases (microbiology)</term><term>Structure-Activity Relationship (MeSH)</term><term>Tobacco (drug effects)</term><term>Tobacco (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Ail (composition chimique)</term><term>Antifongiques (pharmacologie)</term><term>Composés allyliques (pharmacologie)</term><term>Disulfures (pharmacologie)</term><term>Huile essentielle (pharmacologie)</term><term>Maladies des plantes (microbiologie)</term><term>Parties aériennes de plante (composition chimique)</term><term>Phytophthora (effets des médicaments et des substances chimiques)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Relation structure-activité (MeSH)</term><term>Tabac (effets des médicaments et des substances chimiques)</term><term>Tabac (microbiologie)</term><term>Tests de sensibilité microbienne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Allyl Compounds</term><term>Antifungal Agents</term><term>Disulfides</term><term>Oils, Volatile</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Garlic</term><term>Plant Components, Aerial</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Ail</term><term>Parties aériennes de plante</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Phytophthora</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Phytophthora</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antifongiques</term><term>Composés allyliques</term><term>Disulfures</term><term>Huile essentielle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term><term>Microbial Sensitivity Tests</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Relation dose-effet des médicaments</term><term>Relation structure-activité</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study explored the chemical compositions of garlic essential oil, the inhibitory activity of garlic essential oil and diallyl disulfide (DADS) against <i>Phytophthora nicotianae</i>, and the effects on mycelial plasma membrane permeability and <i>P. nicotianae</i> inhibition. In total, 29 compounds were detected in garlic essential oil, of which 26 were detected by gas chromatography‒mass spectrometry (GC-MS) and 21 by headspace solid-phase microextraction (HS-SPME) GC-MS. DADS (60.12% and 19.09%) and trisulfide di-2-propenyl (14.18% and 17.98%) were the major components identified by HS-SPME GC-MS and GC-MS analysis, respectively. Half-inhibitory concentration (Ec50, antagonism) and minimum inhibitory concentration (MIC, fumigation) of DADS against <i>P. nicotianae</i> were 150.83 μL/L and 20 μL/L, respectively, while Ec50 of garlic essential oil was 1108.25 μL/L. Mycelial membrane permeability gradually increased in a concentration-dependent manner, and cell death increased at 450 μL/L DADS. Furthermore, DADS treatment significantly reduced the incidence of tobacco black shank and the number of <i>P. nicotianae</i> pathogens in rhizosphere soil. DADS also promoted root development of tobacco seedlings at low concentrations, which was inhibited at high concentrations. Therefore, DADS may play an important role in the antifungal effect against <i>P. nicotianae</i> by destroying mycelial cell membrane integrity, causing an increase in cell membrane permeability, and leading to cell death.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31640228</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>22</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2218-273X</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>10</Issue><PubDate><Year>2019</Year><Month>10</Month><Day>21</Day></PubDate></JournalIssue><Title>Biomolecules</Title><ISOAbbreviation>Biomolecules</ISOAbbreviation></Journal><ArticleTitle>The Antifungal Effect of Garlic Essential Oil on <i>Phytophthora nicotianae</i> and the Inhibitory Component Involved.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E632</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/biom9100632</ELocationID><Abstract><AbstractText>This study explored the chemical compositions of garlic essential oil, the inhibitory activity of garlic essential oil and diallyl disulfide (DADS) against <i>Phytophthora nicotianae</i>, and the effects on mycelial plasma membrane permeability and <i>P. nicotianae</i> inhibition. In total, 29 compounds were detected in garlic essential oil, of which 26 were detected by gas chromatography‒mass spectrometry (GC-MS) and 21 by headspace solid-phase microextraction (HS-SPME) GC-MS. DADS (60.12% and 19.09%) and trisulfide di-2-propenyl (14.18% and 17.98%) were the major components identified by HS-SPME GC-MS and GC-MS analysis, respectively. Half-inhibitory concentration (Ec50, antagonism) and minimum inhibitory concentration (MIC, fumigation) of DADS against <i>P. nicotianae</i> were 150.83 μL/L and 20 μL/L, respectively, while Ec50 of garlic essential oil was 1108.25 μL/L. Mycelial membrane permeability gradually increased in a concentration-dependent manner, and cell death increased at 450 μL/L DADS. Furthermore, DADS treatment significantly reduced the incidence of tobacco black shank and the number of <i>P. nicotianae</i> pathogens in rhizosphere soil. DADS also promoted root development of tobacco seedlings at low concentrations, which was inhibited at high concentrations. Therefore, DADS may play an important role in the antifungal effect against <i>P. nicotianae</i> by destroying mycelial cell membrane integrity, causing an increase in cell membrane permeability, and leading to cell death.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yaochen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. wangyaochen2020@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Keke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. kekewei1995@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Xiaobin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100, China. hanxiaobin2011@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Donglin</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhaodonglin@caas.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Yanfen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhengyanfen@caas.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chao</LastName><ForeName>Jianmin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. caojianmin@caas.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gou</LastName><ForeName>Jianyu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Biological Organic Fertilizer Engineering Technology Center of China Tobacco, Zunyi 563100, China. goujianyu1975@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kong</LastName><ForeName>Fanyu</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0002-5853-3737</Identifier><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. kongfanyu@caas.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Cheng-Sheng</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Marine Agriculture Research Center, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, China. zhangchengsheng@caas.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Biomolecules</MedlineTA><NlmUniqueID>101596414</NlmUniqueID><ISSNLinking>2218-273X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000498">Allyl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004220">Disulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009822">Oils, Volatile</NameOfSubstance></Chemical><Chemical><RegistryNumber>5HI47O6OA7</RegistryNumber><NameOfSubstance UI="C028009">diallyl disulfide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000498" MajorTopicYN="N">Allyl Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004220" MajorTopicYN="N">Disulfides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005737" MajorTopicYN="N">Garlic</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009822" MajorTopicYN="N">Oils, Volatile</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D035261" MajorTopicYN="N">Plant Components, Aerial</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Phytophthora nicotianae</Keyword><Keyword MajorTopicYN="Y">biofumigant</Keyword><Keyword MajorTopicYN="Y">diallyl disulfide</Keyword><Keyword MajorTopicYN="Y">garlic essential oil</Keyword><Keyword MajorTopicYN="Y">volatiles</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>10</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31640228</ArticleId><ArticleId IdType="pii">biom9100632</ArticleId><ArticleId 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uniqKey="Wang Y" first="Yaochen" last="Wang">Yaochen Wang</name></noRegion><name sortKey="Chao, Jianmin" sort="Chao, Jianmin" uniqKey="Chao J" first="Jianmin" last="Chao">Jianmin Chao</name><name sortKey="Gou, Jianyu" sort="Gou, Jianyu" uniqKey="Gou J" first="Jianyu" last="Gou">Jianyu Gou</name><name sortKey="Han, Xiaobin" sort="Han, Xiaobin" uniqKey="Han X" first="Xiaobin" last="Han">Xiaobin Han</name><name sortKey="Kong, Fanyu" sort="Kong, Fanyu" uniqKey="Kong F" first="Fanyu" last="Kong">Fanyu Kong</name><name sortKey="Wei, Keke" sort="Wei, Keke" uniqKey="Wei K" first="Keke" last="Wei">Keke Wei</name><name sortKey="Zhang, Cheng Sheng" sort="Zhang, Cheng Sheng" uniqKey="Zhang C" first="Cheng-Sheng" last="Zhang">Cheng-Sheng Zhang</name><name sortKey="Zhao, Donglin" sort="Zhao, Donglin" uniqKey="Zhao D" first="Donglin" last="Zhao">Donglin Zhao</name><name sortKey="Zheng, Yanfen" sort="Zheng, Yanfen" uniqKey="Zheng Y" first="Yanfen" last="Zheng">Yanfen 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